Exploiting bacteriophage proteomes: the hidden biotechnological potential

SB Santos, AR Costa, C Carvalho, FL Nóbrega… - Trends in …, 2018 - cell.com
Bacteriophages encode many distinct proteins for the successful infection of a bacterial host.
Each protein plays a specific role in the phage replication cycle, from host recognition …

[HTML][HTML] Genetic engineering of bacteriophages against infectious diseases

Y Chen, H Batra, J Dong, C Chen, VB Rao… - Frontiers in …, 2019 - frontiersin.org
Bacteriophages (phages) are the most abundant and widely distributed organisms on Earth,
constituting a virtually unlimited resource to explore the development of biomedical …

Engineering bacteriophages as versatile biologics

S Kilcher, MJ Loessner - Trends in microbiology, 2019 - cell.com
Viruses of bacteria (bacteriophages or phages) are highly evolved nanomachines that
recognize bacterial cell walls, deliver genetic information, and kill or transform their targets …

[HTML][HTML] Approaches to optimize therapeutic bacteriophage and bacteriophage-derived products to combat bacterial infections

M Reuter, DH Kruger - Virus Genes, 2020 - Springer
The emerging occurrence of antibiotic-resistant bacterial pathogens leads to a recollection
of bacteriophage as antimicrobial therapeutics. This article presents a short overview of the …

[HTML][HTML] Bacteriophage–Host Interactions and the Therapeutic Potential of Bacteriophages

LMT Dicks, W Vermeulen - Viruses, 2024 - mdpi.com
Healthcare faces a major problem with the increased emergence of antimicrobial resistance
due to over-prescribing antibiotics. Bacteriophages may provide a solution to the treatment …

[HTML][HTML] Bacteriophage bioengineering: A transformative approach for targeted drug discovery and beyond

L Cui, S Veeranarayanan, K Thitiananpakorn… - Pathogens, 2023 - mdpi.com
Bacteriophages, the viruses that infect and replicate within bacteria, have long been
recognized as potential therapeutic agents against bacterial infections. The rise of antibiotic …

[HTML][HTML] Bacteriophage procurement for therapeutic purposes

B Weber-Dąbrowska, E Jończyk-Matysiak… - Frontiers in …, 2016 - frontiersin.org
Bacteriophages (phages), discovered 100 years ago, are able to infect and destroy only
bacterial cells. In the current crisis of antibiotic efficacy, phage therapy is considered as a …

Genetic engineering of bacteriophages: Key concepts, strategies, and applications

W Hussain, X Yang, M Ullah, H Wang, A Aziz… - Biotechnology …, 2023 - Elsevier
Bacteriophages are the most abundant biological entity in the world and hold a tremendous
amount of unexplored genetic information. Since their discovery, phages have drawn a great …

[HTML][HTML] Bacteriophage-based tools: recent advances and novel applications

L O'sullivan, C Buttimer, O McAuliffe, D Bolton… - …, 2016 - ncbi.nlm.nih.gov
Bacteriophages (phages) are viruses that infect bacterial hosts, and since their discovery
over a century ago they have been primarily exploited to control bacterial populations and to …

Applications of designer phage encoding recombinant gene payloads

DS Schmitt, SD Siegel, K Selle - Trends in Biotechnology, 2023 - cell.com
Advances in genetic engineering, synthetic biology, and DNA sequencing have transformed
the re-emergent therapeutic bacteriophage field. The increasing rate of multidrug resistant …