The EWS/FLI1 fusion gene is well characterized as a driver of Ewing's sarcoma. Bi-shRNA
EWS/FLI1 is a functional plasmid DNA construct that transcribes both siRNA and miRNA-like …

Existing data identify EWS–FLI1 as indispensable for sustained Ewing's sarcoma growth
and as the ideal therapeutic target in this disease. The siRNA may hold great promises as a …

The EWS/Fli‐1 fusion gene, a product of the translocation t (11; 22, q24; q12), is detected in
85% of Ewing sarcomas and primitive neuroectodermal tumors. It is thought to be a …

The development of effective, systemic therapies for metastatic cancer is highly desired. We
show here that the systemic delivery of sequence-specific small interfering RNA (siRNA) …

The genetic hallmark of the Ewing sarcoma family of tumours (ESFT) is the presence of the t
(11; 22)(q24; q12) translocation, present in up to 85% of cases of ESFT, which creates the …

EWS-FLI1 is a chromosome translocation-derived chimeric transcription factor that has a
central and rate-limiting role in the pathogenesis of Ewing's sarcoma. Although the EWS …

The EWS/Fli-1 fusion gene encodes an oncogenic fusion protein. The fusion is a product of
the translocation t (11; 22)(q24; q12), which is detected in 85% of Ewing sarcoma and …

Purpose: To show the efficacy of targeting EWS/FLI-1 expression with a combination of
specific antisense oligonucleotides and rapamycin for the control of Ewing's sarcoma (EWS) …

We have used structured antisense oligonucleotides (AON), which are protected against
extra and intracellular degradation by their internal structure. We have shown that if correctly …

The EWS–Fli1 fusion gene encodes for a chimeric oncogenic transcription factor considered
to be the cause of the Ewing sarcoma. The efficiency of small interfering RNAs (siRNAs) …