Nascent transcription occurs at nuclear foci of concentrated, hyperphosphorylated RNA
polymerase II (RNAPII). We investigate RNAPII localization, distal gene coassociation, and …

In the eukaryotic nucleus, genes are transcribed in transcription factories. In the present
review, we re-evaluate the models of transcription factories in the light of recent and older …

The intranuclear position of many genes has been correlated with their activity state,
suggesting that migration to functional subcompartments may influence gene expression …

Transcription is a fundamental step in gene expression, yet it remains poorly understood at a
cellular level. Visualization of transcription sites and active genes has led to the suggestion …

Cell size varies during the cell cycle and in response to external stimuli. This requires the
tight coordination, or" scaling," of mRNA and protein quantities with the cell volume in order …

Transcription is regulated by the state of phosphorylation of a heptapeptide repeat known as
the carboxy-terminal domain (CTD) present in the largest subunit of RNA polymerase II …

Initiation and regulation of transcription by RNA polymerase II (RNAPII) in eukaryotes rely on
the transcriptional regulatory elements. Promoters and enhancers share similar …

In eukaryotes, all genetic processes take place in the cell nucleus, where DNA is packaged
as chromatin in'beads-on-a-string'nucleosome arrays. RNA polymerase II (RNAPII) …

Despite the well-established role of nuclear organization in the regulation of gene
expression, little is known about the reverse: how transcription shapes the spatial …

Metazoan transcription is controlled through either coordinated recruitment of transcription
machinery to the gene promoter or regulated pausing of RNA polymerase II (Pol II) in early …