Patients with the dedicator of cytokinesis 8 (DOCK8) immunodeficiency syndrome suffer
from recurrent viral and bacterial infections, hyper–immunoglobulin E levels, eczema, and …

The lineage commitment of CD4+ T cells is coordinately regulated by signals through the T
cell receptor and cytokine receptors, yet how these signals are integrated remains elusive …

Human microbiome studies have revealed the intricate interplay of host immunity and
bacterial communities to achieve homeostatic balance. Healthy skin microbial communities …

DOCK8 mutations result in an inherited combined immunodeficiency characterized by
increased susceptibility to skin and other infections. We show that when DOCK8-deficient T …

To migrate efficiently through the interstitium, dendritic cells (DCs) constantly adapt their
shape to the given structure of the extracellular matrix and follow the path of least resistance …

Recently, patients with mutations in DOCK8 have been reported to have a combined
immunodeficiency characterized by cutaneous viral infections and allergies. NK cells …

Mutations of DOCK8 in humans cause a combined immunodeficiency characterized by
atopic dermatitis with high serum IgE levels. However, the molecular link between DOCK8 …

Dendritic cells (DCs) are the primary leukocytes responsible for priming T cells. To find and
activate naïve T cells, DCs must migrate to lymph nodes, yet the cellular programs …

We describe a homozygous copy-number variant that disrupts the function of Dock2 in a
commercially available C57BL/6 mouse strain that is widely used for backcrossing. This …

Autosomal dominant hyper-IgE syndrome (AD-HIES), characterised by eczema, increased
susceptibility to skin and lung infections, elevated IgE and skeletal abnormalities is …