The classic pathologic hallmarks of Alzheimer's disease (AD) are amyloid plaques and
neurofibrillary tangles (AD neuropathologic changes, or ADNC). However, brains from …

Introduction Alzheimer's disease (AD) is the world leading cause of dementia. Early
detection of AD is essential for faster and more efficacious usage of therapeutics and …

Background Genome wide association studies (GWAS) have identified many genetic
variants associated with increased risk of Alzheimer's disease (AD). These susceptibility loci …

Background We have increasing information on the role of certain genetic variants in a wide
variety of molecular traits and endophenotypes of Alzheimer's disease (AD), but their …

We investigated the genetic overlap between Alzheimer's disease (AD) and Parkinson's
disease (PD). Using summary statistics (P-values) from large recent genome-wide …

Limited ancestral diversity has impaired our ability to detect risk variants more prevalent in
non-European ancestry groups in genome-wide association studies (GWAS). We …

Background Genomewide association (GWA) studies have recently implicated 4 novel
Alzheimer disease (AD) susceptibility loci (GAB2, GOLM1, and 2 uncharacterized loci to …

The MAPT H1 haplotype has been linked to several disorders, but its relationship with
Alzheimer's disease (AD) remains controversial. A rare variant in MAPT (p. A152T) has been …

Objective: To investigate the top late-onset Alzheimer disease (LOAD) risk loci detected or
confirmed by the International Genomics of Alzheimer's Project for association with brain …

Abstract Introduction The MAPT H1 haplotype has been associated with several
neurodegenerative diseases. We were interested in exploring the role of MAPT haplotypic …