Radioiodination of Internalizing Monoclonal Antibodies Using N-Succinimidyl 5-Iodo-3-Pyridinecarboxylate
CJ Reist, PK Garg, KL Alston, DD Bigner, MR Zalutsky - Cancer research, 1996 - AACR
Monoclonal antibodies (mAbs) that internalize following binding to cell-surface receptors
require radiolabeling approaches that minimize loss of radioactivity from the cell after …
require radiolabeling approaches that minimize loss of radioactivity from the cell after …
Tentative biological model for the localization of radiolabelled antibody in tumor: the importance of immunoreactivity
SM Larson - Nucl. Med. Biol.;(United Kingdom), 1986 - osti.gov
The model is based on the following assumptions, some of which have preliminary support
in experimental studies: 1. That the binding reaction between tumor antigen and antibody is …
in experimental studies: 1. That the binding reaction between tumor antigen and antibody is …
125I-glycoconjugate labels for identifying sites of protein catabolism in vivo: effect of structure and chemistry of coupling to protein on label entrapment in cells after …
JL Strobel, JW Baynes, SR Thorpe - Archives of biochemistry and …, 1985 - Elsevier
Residualizing radioactive labels are designed to remain entrapped within cells following
degradation of a carrier protein, and have been used for identification of the tissue and …
degradation of a carrier protein, and have been used for identification of the tissue and …
Inhibition of catabolism of radiolabeled antibodies by tumor cells using lysosomotropic amines and carboxylic ionophores
OW Press, K DeSantes, SK Anderson, F Geissler - Cancer research, 1990 - AACR
The rates of degradation of radioiodinated monoclonal antibodies (MoAbs) by malignant T-
and B-lymphoid cells were studied in the presence and absence of a variety of …
and B-lymphoid cells were studied in the presence and absence of a variety of …
p-Iodobenzoyl groups as a paired label for in vivo protein distribution studies: Specific localization of anti-tissue antibodies
M Blau, AC Johnson, D Pressman - The International journal of applied …, 1958 - Elsevier
Measurements of the specific in vivo localizing properties of radiolabeled anti-tissue
antibodies are always complicated by the nonspecific pickup of proteins by tissues …
antibodies are always complicated by the nonspecific pickup of proteins by tissues …
Polyclonal natural antitumor antibody binding dynamics: preferential release of surface membrane molecules and increased metastasis.
DA Chow, XY Yuan, DF Tough - Invasion & Metastasis, 1992 - europepmc.org
Flow cytometry revealed the dynamic nature of polyclonal whole serum naturally occurring
IgG and IgM antibody binding to the syngeneic murine T cell lymphomas SL2-5, L5178Y-F9 …
IgG and IgM antibody binding to the syngeneic murine T cell lymphomas SL2-5, L5178Y-F9 …
In vivo evaluation of radiolabelled antibodies with antigen-coated polymer particles in diffusion chambers
JG Fjeld, HB Benestad, T Stigbrand… - Journal of immunological …, 1988 - Elsevier
A method for the evaluation of in vivo immunolocalization of labelled monoclonal antibodies
(MoAb) is presented. The technique is an alternative to the nude mouse xenograft system …
(MoAb) is presented. The technique is an alternative to the nude mouse xenograft system …
[PDF][PDF] Inhibition of autoradiolysis of radiolabeled monoclonal antibodies by cryopreservation
RL Wahl, J Wissing, R del Rosario… - Journal of Nuclear …, 1990 - Soc Nuclear Med
METHODS Three monoclonal antibodies were evaluated in this study: 5G6. 4, a murine
IgG2a monoclonal reactive with ovarian and many other carcinomas (7), 763.24 T, a murine …
IgG2a monoclonal reactive with ovarian and many other carcinomas (7), 763.24 T, a murine …
Preembedding immuno-labelling
G Griffiths, G Griffiths - Fine Structure Immunocytochemistry, 1993 - Springer
Two different kinds of preembedding strategies will be considered in this chapter. The first
can be referred to as the “intact cell” approach and the second as the “cell ghost” approach …
can be referred to as the “intact cell” approach and the second as the “cell ghost” approach …
Physiology of monoclonal antibody accretion by tumors
H Sands, PL Jones - Cancer imaging with radiolabeled antibodies, 1990 - Springer
The method for the production of monoclonal antibodies that was introduced by Kohler and
Milstein in 1976 gave the promise of generating reagents with exquisite specificity and great …
Milstein in 1976 gave the promise of generating reagents with exquisite specificity and great …