Neutrophils are first-responders, providing early protection against invading pathogens.
Recent findings have revealed a temporal dimension to neutrophil function, associated with …

Highlights•Neutrophils are increasingly recognized as multi-faceted immune cells.•In aged
hosts, neutrophils show inaccurate chemotaxis and reduced NET formation.•Neutrophils …

Under steady-state conditions, aged neutrophils are removed from the circulation in bone
marrow, liver, and spleen, thereby maintaining myeloid cell homeostasis. The fate of these …

Over the past millennia, life expectancy has drastically increased. While a mere 25 years
during Bronze and Iron ages, life expectancy in many European countries and in Japan is …

In the armoury of the immune system developed to combat the various micro‐organisms that
could invade the host, the neutrophil forms the first line of defence against rapidly dividing …

Neutrophils are recognized as an essential part of the innate immune response, but an
active debate still exists regarding the life cycle of these cells. Neutrophils first differentiate in …

Human neutrophils are activated by a wide array of compounds through their receptors. This
elicits their classical functions, such as chemotaxis, phagocytosis, and the production of …

Despite increasing longevity, many old people are not in good health. There has been an
increase in the prevalence of age-associated multi-morbidity (two or more chronic conditions …

As humans age, their morbidity and mortality from infection increases, their response to
vaccination declines and they have an increased incidence of inflammatory diseases and …

It is well known that the immune response decreases during aging, leading to a higher
susceptibility to infections, cancers and autoimmune disorders. Most widely studied have …