Since new and dangerous influenza virus strains, such as H5N1 “avian flu” and more
recently the swine-origin H1N1 “swine flu”, are constantly evolving, the need for effective anti …

Influenza is a century-old disease that continues to baffle humans by its frequently changing
nature, seasonal epidemics, and occasional pandemics. Approximately 9% of the world's …

Every year, influenza epidemics cause numerous deaths and millions of hospitalizations, but
the most frightening effects are seen when new strains of the virus emerge from different …

Only four drugs are approved for the specific treatment of acute influenza infections
worldwide. These drugs address either the viral neuraminidase or the M2-channel but suffer …

In the first part of this overview, we described the life cycle of the influenza virus and the
pharmacological action of the currently available drugs. This second part provides an …

Infections by influenza virus constitute a major and recurrent threat for human health.
Together with vaccines, antiviral drugs play a key role in the prevention and treatment of …

Seasonal and pandemic influenza virus infections not only pose a serious threat to human
health but also cause tremendous economic losses and social burdens. However, due to the …

Prevention and treatment of influenza virus infection is an ongoing unmet medical need.
Each year, thousands of deaths and millions of hospitalizations are attributed to influenza …

The influenza virus causes one of the most prevalent and lethal infectious viral diseases of
the respiratory system; the disease progression varies from acute self-limiting mild fever to …

The influenza virus types A, B, and C belong to the family Orthomyxoviridae. Influenza B and
C viruses are predominantly human pathogens, whereas influenza A virus spreads not only …