Clostridioides difficile is a gram-positive, spore-forming, obligate anaerobe that infects the
colon. C. difficile is estimated to cause nearly half a million cases in the United States …

Clostridiodes difficile infection (CDI) continues to be one of the leading causes of healthcare-
acquired diarrhea and infections, and recurrence is the biggest challenge in its …

Metronidazole and vancomycin remain the front‐line therapies for most Clostridium difficile
infections (CDI). However, recurrent CDI occurs in∼ 25% of patients, causing significant …

Clostridioides difficile is a Gram-positive, spore-forming anaerobic bacterial pathogen that
causes severe gastrointestinal infection in humans. This review provides background …

We are in the midst of a resurgence of Clostridium difficile infection (CDI) in North America
and Europe for which morbidity and mortality are higher than ever seen. C. difficile has risen …

Abstract Background. Patients with recurrent Clostridium difficile infection (CDI) have a≥
60% risk of relapse, as conventional therapies do not address the underlying …

Abstract Purpose of Review Antibiotic use is the most important modifiable risk factor for the
development of Clostridioides difficile infection (CDI). In addition, up to a quarter of patients …

Clostridioides difficile (C. difficile) is a gram-positive, anaerobic spore-forming bacterium and
a major cause of antibiotic-associated diarrhea. Humans are naturally resistant to C. difficile …

Clostridium difficile is the most frequent cause of nosocomial antibiotic-associated diarrhea.
The incidence of C. difficile infection (CDI) has been rising worldwide with subsequent …

With the end of the golden era of antibiotic discovery, the emergence of a new post-antibiotic
age threatens to thrust global health and modern medicine back to the pre-antibiotic era …