Antibiotics strongly disrupt the human gut microbiota, which in consequence loses its
colonization resistance capacity, allowing infection by opportunistic pathogens such as …

Background Gut microbiota alterations and resulting changes in metabolites involved in
colonization resistance and host responses, including bile acids (BA) and short-chain fatty …

Infection with toxigenic Clostridioides difficile in the setting of antibiotic administration has
become the exemplar of a disease where the indigenous microbiota plays a central role in …

Introduction: Clostridium difficile infection (CDI) has become a significant healthcare-
associated infection and is strongly associated with antibiotic use. Practice guidelines have …

Clostridium difficile infection (CDI) has emerged as the most frequently encountered cause
of nosocomial diarrhea worldwide. 1 The human intestinal microbiota is a diverse ecosystem …

Treatment options for Clostridium difficile infection (CDI) remain limited despite this usually
nosocomial infection posing an urgent threat to public health. A major paradox of the …

Introduction The gut microbiome is implicated in Clostridioides difficile infection (CDI) and
recurrent CDI (rCDI). Areas covered This review covers the mechanisms by which …

Background Clostridium difficile is the leading cause of antibiotic-associated diarrhoea, both
in healthcare facilities and in the community. The recurrence rate of C. difficile infection (CDI) …

Clostridioides difficile infection (CDI) has emerged as a major health problem worldwide. A
major risk factor for disease development is prior antibiotic use, which disrupts the normal …

Microbiota restoration therapy has become a standard treatment for recurrent Clostridioides
difficile infection (rCDI). In this article, we review the studies supporting the licensure of two …