HIV infection alters the human epigenetic landscape
Many complex diseases or traits are the results of both genetic and environmental factors.
The environmental factors affect the human body by modifying its epigenetics, which …
The environmental factors affect the human body by modifying its epigenetics, which …
Deciphering DNA methylation in HIV infection
T Arumugam, U Ramphal, T Adimulam… - Frontiers in …, 2021 - frontiersin.org
With approximately 38 million people living with HIV/AIDS globally, and a further 1.5 million
new global infections per year, it is imperative that we advance our understanding of all …
new global infections per year, it is imperative that we advance our understanding of all …
Effect of HIV infection and antiretroviral therapy initiation on genome-wide DNA methylation patterns
A Esteban-Cantos, J Rodríguez-Centeno, JC Silla… - …, 2023 - thelancet.com
Background Previous epigenome-wide association studies have shown that HIV infection
can disrupt the host DNA methylation landscape. However, it remains unclear how …
can disrupt the host DNA methylation landscape. However, it remains unclear how …
Genome-wide characterization of host transcriptional and epigenetic alterations during HIV infection of T lymphocytes
X Zeng, JCC Tsui, M Shi, J Peng, CY Cao… - Frontiers in …, 2020 - frontiersin.org
Background and methods: Host genomic alterations are closely related to dysfunction of
CD4+ T lymphocytes in the HIV–host interplay. However, the roles of aberrant DNA …
CD4+ T lymphocytes in the HIV–host interplay. However, the roles of aberrant DNA …
[HTML][HTML] Genome-wide analysis of DNA methylation associated with HIV infection based on a pair of monozygotic twins
Y Zhang, SK Li, SKW Tsui - Genomics Data, 2015 - Elsevier
Alteration of DNA methylation in mammalian cells could be elicited by many factors,
including viral infections [1]. HIV has shown the ability to interact with host cellular factors to …
including viral infections [1]. HIV has shown the ability to interact with host cellular factors to …
Epigenome-wide differential DNA methylation between HIV-infected and uninfected individuals
Epigenetic control of human immunodeficiency virus-1 (HIV-1) genes is critical for viral
integration and latency. However, epigenetic changes in the HIV-1-infected host genome …
integration and latency. However, epigenetic changes in the HIV-1-infected host genome …
DNA methylation changes in metabolic and immune-regulatory pathways in blood and lymph node CD4+ T cells in response to SIV infections
The molecular mechanisms underlying HIV-induced inflammation, which persists even
during effective long-term treatment, remain incompletely defined. Here, we studied …
during effective long-term treatment, remain incompletely defined. Here, we studied …
Latency-associated DNA methylation patterns among HIV-1 infected individuals with distinct disease progression courses or antiretroviral virologic response
DNA methylation is one of the epigenetic modifications that configures gene transcription
programs. This study describes the DNA methylation profile of HIV-infected individuals with …
programs. This study describes the DNA methylation profile of HIV-infected individuals with …
Abrupt and altered cell-type specific DNA methylation profiles in blood during acute HIV infection persists despite prompt initiation of ART
MJ Corley, C Sacdalan, APS Pang, N Chomchey… - PLoS …, 2021 - journals.plos.org
HIV-1 disrupts the host epigenetic landscape with consequences for disease pathogenesis,
viral persistence, and HIV-associated comorbidities. Here, we examined how soon after …
viral persistence, and HIV-associated comorbidities. Here, we examined how soon after …
Epigenetic modulations in activated cells early after HIV-1 infection and their possible functional consequences
JT Maricato, MN Furtado, MC Takenaka, ERM Nunes… - PLoS …, 2015 - journals.plos.org
Epigenetic modifications refer to a number of biological processes which alter the structure
of chromatin and its transcriptional activity such as DNA methylation and histone post …
of chromatin and its transcriptional activity such as DNA methylation and histone post …