Effects of pregnancy and ethanol treatment on the metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by hamster liver and lung microsomes.
R Jorquera, A Castonguay, HM Schuller - Drug metabolism and disposition, 1992 - ASPET
The tobacco-specific N-nitrosamino 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is
a potent carcinogen in adult Syrian golden hamsters and causes a high incidence of tumors …
a potent carcinogen in adult Syrian golden hamsters and causes a high incidence of tumors …
Effect of tobacco smoke condensate on the metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by adult and fetal hamster microsomes.
R Jorquera, A Castonguay, HM Schuller - Drug metabolism and disposition, 1993 - ASPET
The tobacco-specific N-nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is
a potent carcinogen in Syrian golden hamsters exposed pre-or postnatally to NNK. NNK …
a potent carcinogen in Syrian golden hamsters exposed pre-or postnatally to NNK. NNK …
Metabolism and DNA damage induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in fetal tissues of the Syrian golden hamster
G Rossignol, MA Alaoui-Jamali, A Castonguay… - Cancer Research, 1989 - AACR
The nicotine derived N-nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is
a potent respiratory tract carcinogen in adult Syrian golden hamsters. In this study, the …
a potent respiratory tract carcinogen in adult Syrian golden hamsters. In this study, the …
Perinatal metabolism of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in C57BL mice
A Castonguay, H Tjälve, N Trushin… - Journal of the National …, 1984 - academic.oup.com
Whole-body autoradiography of pregnant C57BL mice given iv injections of carbonyl-14C-
labeled 4-(methylnitro-samino)-1-(3-pyridyl)-1-butanone (NNK) revealed that some …
labeled 4-(methylnitro-samino)-1-(3-pyridyl)-1-butanone (NNK) revealed that some …
Placental transfer of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone instilled intratracheally in Syrian golden hamsters
R Jorquera, A Castonguay, HM Schuller - Cancer research, 1992 - AACR
The tobacco-specific N-nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is
a potent tumorigen in adult Syrian golden hamsters and an active transplacental carcinogen …
a potent tumorigen in adult Syrian golden hamsters and an active transplacental carcinogen …
Low levels of expression of cytochromes P-450 in normal and cancerous fetal pancreatic tissues of hamsters treated with NNK and/or ethanol
L Zhang, DL Weddle, PE Thomas, B Zheng… - Toxicological …, 2000 - academic.oup.com
Previous studies from this laboratory have demonstrated that administration of the tobacco-
specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) to pregnant …
specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) to pregnant …
Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in human placental microsomes
NR Collazo, LG Sultatos - Biochemical pharmacology, 1995 - Elsevier
The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) can
be activated metabolically by cytochrome (s) P450 to DNA-damaging agents that result in …
be activated metabolically by cytochrome (s) P450 to DNA-damaging agents that result in …
In vitro metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by lung cells isolated from Syrian golden hamster
MA Alaoui-Jamali, TE Massey, A Douglas, G Rossignol… - Cancer letters, 1990 - Elsevier
The nicotine derived N-nitrosamine, 4-(methylnitro-samino)-1-(3-pyridyl)-1-butanone (NNK),
is a potent respiratory carcinogen in the Syrian golden hamster. The in vitro metabolism of …
is a potent respiratory carcinogen in the Syrian golden hamster. The in vitro metabolism of …
The Tobacco-specific Nitrosamine 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone Is an Active Transplancental Carcinogen in Syrian Golden Hamsters
E Correa, PA Joshi, A Castonguay, HM Schüller - Cancer Research, 1990 - AACR
Abstract The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
(NNK) is a potent carcinogen in adult laboratory rodents. Our previous studies have shown …
(NNK) is a potent carcinogen in adult laboratory rodents. Our previous studies have shown …
Use of precision-cut tissue slices in organ culture to study metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and 4-(methylnitrosamino)-1-(3-pyridyl …
E Richter, S Friesenegger, J Engl, AR Tricker - Toxicology, 2000 - Elsevier
The pharmacokinetics of in vitro metabolism of the tobacco-specific nitrosamine, 4-
(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK; concentration range 0.03–250 μM) and …
(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK; concentration range 0.03–250 μM) and …