Antimicrobial plant metabolites: structural diversity and mechanism of action

NS Radulovic, PD Blagojevic… - Current medicinal …, 2013 - ingentaconnect.com
Microbial infectious diseases continue to be one of the leading causes of morbidity and
mortality. It has been estimated that microbial species comprise about 60% of the Earth's …

Plant secondary metabolites in the battle of drugs and drug-resistant bacteria: new heroes or worse clones of antibiotics?

CL Gorlenko, HY Kiselev, EV Budanova… - Antibiotics, 2020 - mdpi.com
Infectious diseases that are caused by bacteria are an important cause of mortality and
morbidity in all regions of the world. Bacterial drug resistance has grown in the last decades …

Plant natural products targeting bacterial virulence factors

LN Silva, KR Zimmer, AJ Macedo, DS Trentin - Chemical reviews, 2016 - ACS Publications
Decreased antimicrobial efficiency has become a global public health issue. The paucity of
new antibacterial drugs is evident, and the arsenal against infectious diseases needs to be …

Biosynthesis investigations of terpenoid, alkaloid, and flavonoid antimicrobial agents derived from medicinal plants

W Huang, Y Wang, W Tian, X Cui, P Tu, J Li, S Shi… - Antibiotics, 2022 - mdpi.com
The overuse of antibiotics in the past decades has led to the emergence of a large number
of drug-resistant microorganisms. In recent years, the infection rate caused by multidrug …

Natural products as antibacterial agents

GB Mahady, Y Huang, BJ Doyle, T Locklear - Studies in natural products …, 2008 - Elsevier
For thousands of years medicinal plants have played a significant role in the treatment of a
wide range of medical conditions, including infectious diseases. Some naturally occurring …

Antimicrobial natural products: an update on future antibiotic drug candidates

M Saleem, M Nazir, MS Ali, H Hussain, YS Lee… - Natural product …, 2010 - pubs.rsc.org
Covering: 2000 to 2008 Over the last decade, it has become clear that antimicrobial drugs
are losing their effectiveness due to the evolution of pathogen resistance. There is therefore …

Secondary plant metabolites as potent drug candidates against antimicrobial-resistant pathogens

K Keita, C Darkoh, F Okafor - SN Applied Sciences, 2022 - Springer
Antibiotic resistance is a major public health threat of the twenty-first century and represents
an important risk to the global economy. Healthcare-associated infections mainly caused by …

Opportunities for plant natural products in infection control

AM Salam, CL Quave - Current opinion in microbiology, 2018 - Elsevier
The continued spread of antimicrobial resistance represents one of the most serious
infectious disease threats to global health. There is consensus that a key component of …

Ethnobotany and the role of plant natural products in antibiotic drug discovery

G Porras, F Chassagne, JT Lyles, L Marquez… - Chemical …, 2020 - ACS Publications
The crisis of antibiotic resistance necessitates creative and innovative approaches, from
chemical identification and analysis to the assessment of bioactivity. Plant natural products …

Plant-derived antimicrobial compounds: alternatives to antibiotics

D Savoia - Future microbiology, 2012 - Future Medicine
The increasing incidence of drug-resistant pathogens has drawn the attention of the
pharmaceutical and scientific communities towards studies on the potential antimicrobial …