Context: Genetic aberration in phosphatidylinositol 3-kinase (PI3K)/AKT pathway has been
detected in numerous and diverse human cancers. PIK3CA, which encodes for the catalytic …

Context: As in many other human cancers, overactivation of the phosphotidylinositol 3-
kinase (PI3K)/Akt signaling pathway occurs frequently in thyroid cancer, but the mechanism …

Abstract The phosphatidylinositol 3′-kinase (PI3K) pathway is frequently activated in
thyroid carcinomas through the constitutive activation of stimulatory molecules (eg, Ras) …

Context: Genetic alterations in the phosphatidylinositol-3-kinase (PI3K)/Akt pathway and
their role in thyroid tumor pathogenesis in Chinese people remain undefined. Objective: The …

Purpose: To investigate the overall occurrence and relationship of genetic alterations in the
phosphatidylinositol 3-kinase (PI3K)/Akt pathway in thyroid tumors and explore the scope of …

Genetic alterations in the PIK3CA gene of the phosphoinositide 3-kinase (PI3K)/AKT
pathway have been found in many human tumors, but they have not been explored in …

Background: Aberrant activation of the phosphatidylinositol-3 kinase (PI3K)/Akt pathway
plays a fundamental role in thyroid tumorigenesis, particularly in follicular thyroid cancer …

Purpose: The extent to which routine genomic sequencing can identify relevant secondary
genomic alterations among BRAFV600E-mutant papillary thyroid carcinoma (PTC) is …

Abstract Phosphatidylinositol-4, 5-bisphosphate 3-kinase catalytic subunit α (PIK3CA) is a
central element of a signaling pathway involved in cell proliferation, survival, and growth …

Patients with poorly differentiated thyroid cancers (PDTC), anaplastic thyroid cancers (ATC),
and radioactive iodine-refractory (RAIR) differentiated thyroid cancers have a high mortality …