Patients with poorly differentiated thyroid cancers (PDTC), anaplastic thyroid cancers (ATC),
and radioactive iodine-refractory (RAIR) differentiated thyroid cancers have a high mortality …

Phosphatidylinositol 3‐kinases (PI3K) are a group of heterodimeric lipid kinases that
regulate many cellular processes. Gene amplification and somatic mutations mainly within …

Purpose: Recent studies have reported high frequencies of somatic mutations in the
phosphoinositide-3-kinase catalytic α (PIK3CA) gene in several human solid tumors …

Context: Anaplastic thyroid carcinoma (ATC) can occur in the setting of differentiated thyroid
carcinoma (DTC), which suggests a continuum in malignant progression from DTC to ATC …

Context: Genetic alterations in receptor tyrosine kinases (RTKs) and phosphatidylinositol 3-
kinase (PI3K)/Akt and MAPK pathways have not been fully defined in anaplastic and …

Abstract Phosphatidylinositol 3-kinases (PI3Ks) are heterodimeric lipid kinases that regulate
cellular activities such as proliferation, survival, motility and morphology. Recent studies …

Phosphatidylinositol 3-kinases (PI3Ks) are a group of lipid kinases that regulate signaling
pathways involved in cell proliferation, adhesion, survival and motility. The PI3K pathway is …

The frequently altered phosphatidylinositol-3-kinase (PI3K)/Akt signaling pathway is
involved in the regulation of cellular processes required for breast carcinogenesis. The aim …

OBJECTIVES: The phosphatidylinositol 3-kinase/AKT axis is an important cell-signaling
pathway that mediates cell proliferation and survival, two biological processes that regulate …

PIK3CA belongs to the phosphatidylinositol 3‐kinases (PI3Ks) family, which play an
important role in proliferation, adherence, transformation and cell survival through the …