Phosphatidylinositol 3-kinases (PI3Ks) are important regulators of signaling pathways. To
determine whether PI3Ks are genetically altered in human cancers, we recently analyzed …

The phosphatidylinositol 3-kinase (PI3K) signaling pathway is an important regulator of
many cellular events, including apoptosis, proliferation, and motility. Enhanced activation of …

A recent report revealed that phosphoinositide-3-kinase, catalytic, alpha (PIK3CA) gene is
somatically mutated in several types of human cancer, suggesting the mutated PIK3CA gene …

Deregulation of the phosphoinositide 3-kinase (PI3K) pathway contributes to the
development and progression of tumors. Here, we determine that somatic mutations in …

PI3K/AKT signalling pathway controls important cellular processes such as the cell
proliferation and apoptosis. PIK3CA gene encoding a catalytic subunit of the PI3K is mutated …

Purpose: Somatic mutations of PIK3CA, which encodes the p110α catalytic subunit of
phosphatidylinositol 3-kinase, have recently been shown to play an important role in the …

Abstract The phosphatidylinositol 3-kinases (PI3K) are a family of enzymes that relay
important cellular growth control signals. Recently, a large-scale mutational analysis of eight …

Purpose PIK3CA gene encoding a catalytic subunit of the phosphatidylinositol-3-kinase
(PI3K) is mutated and/or amplified in various neoplasia, including lung cancer. Here we …

Class I phosphoinositide 3-kinase (PI3K) enzymes have attracted considerable attention as
drug targets in cancer therapy over the last 20 years. The signaling pathway triggered by …

PIK3CA, which encodes the catalytic subunit, p110-alpha, of phosphatidylinositol 3-kinase
(PI3K), is implicated in the development and progression of numerous neoplasias including …