PIK3CA, which encodes the catalytic subunit, p110-alpha, of phosphatidylinositol 3-kinase
(PI3K), is implicated in the development and progression of numerous neoplasias including …

Abstract Purpose: The phosphatidylinositol 3′-kinase (PI3K) family plays a key regulatory
role in various cancer-associated signal transduction pathways. Here, we investigated the …

Somatic mutations of the PIK3CA gene, which encodes the p110α catalytic subunit of
phosphatidylinositol 3‐kinase (PI3K), are frequent in various cancer types. The majority of …

Abstract Background Phosphatidylinositol-4, 5-bisphosphate 3-kinase, catalytic subunit
alpha (PIK3CA) mutations that activate the PI3K/AKT signaling pathway have been …

Abstract The phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway is one of the most
commonly deregulated pathways in human cancers. PI3K comprises a catalytic (p110α) and …

Breast cancer (BCa) is the most common cancer and the second cause of death among
women. Phosphoinositide 3-kinase (PI3K) signaling pathway has a crucial role in the …

Abstract The phosphoinositide 3-kinase (PI3K) signaling cascade, a key mediator of cellular
survival, growth, and metabolism, is frequently altered in human cancer. Activating mutations …

Abstract Disrupted phosphatidylinositol 3-kinase (PI3K) activity and its effect on the
downstream target AKT plays an important role in malignant diseases. Gain and/or …

Background Papillary thyroid carcinoma (PTC) is the most common malignant thyroid
neoplasm comprising 80–90% of all thyroid malignancies. Molecular changes in thyroid …

A recent study revealed that the p110α (PIK3CA), catalytic subunit of phosphatidylinositol 3-
kinase (PI3K), is somatically mutated in many types of cancer. For example, PIK3CA is …