Summary Purpose BRAF V600E mutation represents the most common oncogenic event in
sporadic papillary thyroid cancer (PTC). There are, however, significant discrepancies …

Abstract The phosphatidylinositol-3 kinase (PI3K) pathway regulates a number of cellular
processes, including cell survival, cell growth, and cell cycle progression. Consequently, this …

PIK3CA codes for a Class IA p110-alpha catalytic subunit of the PI3Ks (phosphatidylinositol
3-kinases) that regulate various signaling pathways important for neoplasia, including cell …

Activating mutations in PIK3CA are frequent in human breast cancer, and phosphoinositide
3-kinase alpha (PI3Kα) inhibitors have been approved for therapy. To characterize …

Abstract Context: The phosphoinositide 3-kinase (PI3K)/Akt pathway is widely postulated to
be an effective therapeutic target in thyroid cancer. Objective: The aim of the study was to …

Background The phosphoinositide 3-kinase (PI3K)/Akt pathway plays a fundamental role in
cell proliferation and survival in human tumorigenesis, including gastric cancer. PIK3CA …

Abstract The phosphatidylinositol 3-kinase (PI3K)–AKT and RAS–MAPK pathways are
deregulated in a wide range of human cancers by gain or loss of function in several of their …

It is now well established that cancer is a genetic disease and that somatic mutations of
oncogenes and tumour suppressor genes are the initiators of the carcinogenic process. The …

The PI3K signaling pathway is dysregulated by a variety of mechanisms in a large fraction of
human tumors. Both mutational and functional analyses have shown that PIK3CA is an …

Activation of the phosphoinositide 3-kinase (PI3K) pathway occurs widely in human cancers.
Although somatic mutations in the PI3K pathway genes PIK3CA and PTEN are known to …