Somatic mutations of the PIK3CA (phosphatidylinostitol 3-kinase catalytic subunit) gene
have been found in human cancer patients. Previous reports suggested that about 4% of …

Background: Papillary thyroid carcinoma (PTC) in young people usually has an aggressive
initial presentation, though a good general prognosis despite recurrences in 10%–20% of …

Phosphoinositide kinases (PIKs) are a group of lipid kinases that are important upstream
activators of various significant signaling pathways. Hyperactivation of the PI3K/AKT/mTOR …

Oncogenic mutations in PIK3CA, which encodes the phosphoinositide-3-kinase (PI3K)
catalytic subunit p110α, occur in∼ 25% of human breast cancers. In this study, we report the …

Breast cancer (BC) is the second most common cause of cancer‐related deaths in women
worldwide. The availability of reliable biomarkers of response/resistance to cancer …

Background While there is strong evidence for phosphatidylinositol 3-kinase (PI3K)
involvement in cancer development, there is limited information about the role of PI3K …

Phosphatidylinositol 3′-kinases are lipid kinases with important roles in neoplasia.
Recently, a very high frequency of somatic mutations in PIK3CA has been reported among a …

Background Although a wide spectrum of inhibitors of the MEK/ERK and PI3K/AKT pathways
have been discovered and entered clinical trials, the effects of their individual use in thyroid …

Purpose: In thyroid cancer clinical trials, agents targeting VEGF receptors (VEGFR) and
RET, among other kinases, have led to partial responses but few complete or durable …

Thyroid papillary carcinoma is the most common endocrine neoplasm and generally carries
a favorable prognosis. However, a small subset of papillary carcinomas transforms into …