Autophagy is a highly regulated cellular pathway for degrading long-lived proteins and is the
only known pathway for clearing cytoplasmic organelles. Autophagy is a major contributor to …

Autophagy is a highly regulated‐cell pathway for degrading long‐lived proteins as well as
for clearing cytoplasmic organelles. Autophagy is a key contributor to cellular homeostasis …

Modulation of autophagy as an anticancer strategy has been widely studied and evaluated
in several cell models. However, little attention has been paid to the metabolic changes that …

Autophagy is a central recycling process, and it plays a complex role in cancer. We
discovered that when autophagy is blocked, cancer cells compensate by increasing …

Autophagy is a critical cellular process that generally protects cells and organisms from
harsh environment, including limitations in adenosine triphosphate (ATP) availability or a …

Autophagy promotes tumor growth and autophagy inhibition drastically reduces tumor
progression in mice. Consequently, there are over 60 clinical trials targeting autophagy in a …

Most cancer cells predominantly produce energy by glycolysis, even in the presence of
adequate oxygen. Therefore, inhibition of glycolysis is a promising cancer treatment target …

Macroautophagy (autophagy hereafter) captures intracellular proteins and organelles and
degrades them in lysosomes. The degradation breakdown products are released from …

Autophagy, as a special programmed cell death, is a critical degradative process that
eliminates intracellular abnormal proteins or damage organelles to balance cell energy and …

Tumorigenesis is often accompanied by metabolic changes that favor rapid energy
production and increased biosynthetic capabilities. These metabolic adaptations promote …