Our evolving understanding of the mechanisms involved in the actions of adenosine on
central neurons during the course of the past three decades has largely been a …

The distribution, molecular structure and role of adenosine A2 receptors in the nervous
system, is reviewed. The adenosine A2a receptor subtype, identified in the nervous system …

Adenosine receptors are divided into two main subtypes, designated A 1 and A 2. Although
the two subtypes are presently defined by structure-activity relationships, the original …

BACKGROUND The present invention relates to substituted 5-amino pyrazolo-4, 3-e-1, 2, 4-
triazolo 1, 5-cpyrimidine adenosine A receptor antagonists, the use of Said compounds in …

Studies done over the last 20 years have clearly shown that the adenosine A2, 4 receptors
are abundant in the striatum of several animal species. A~ A receptors have also been found …

Characterization of the adenosine A2 receptor has been limited due to the lack of available
ligands which have high affinity and selectivity for this adenosine receptor subtype. In the …

BACKGROUND The present invention relates to substituted 5-amino pyrazolo-4, 3-e-1, 2, 4-
triazolo 1, 5-cpyrimidine adenosine A receptor antagonists, the use of Said compounds in …

BACKGROUND This invention relates to substituted 1, 2, 4-triazolo 1.5-c pyrimidine
adenosine A receptor antagonists, the use of said compounds in the treatment of central …

1. Adenosine is an endogenous neuromodulator that exerts its depressant effect on neurons
by acting on the A 1 adenosine receptor subtype. Excitatory actions of adenosine, mediated …

Adenosine participates in the physiology of central and peripheral tissues through several
subtypes of G-protein-coupled receptors. Positively linked to adenylate cyclase, A2 …