Chondroitin sulphate (CS) proteoglycans are up-regulated in the extracellular matrix of
injured nerves and constitute barriers to axonal re-growth. Chondroitin sulphate ABC lyases …

Chondroitin sulphate proteoglycans (CSPGs) up-regulated in the extracellular matrix of
injured nerves, constitute barriers to nerve regeneration. Cleavage of CS using …

Chondroitin sulphate proteoglycans (CSPGs) upregulated at sites of nerve injury restrict
axonal regrowth and hamper nerve regeneration. Digestion of the CS moieties in vivo with …

In Injured nerves, chondroitin sulphate (CS) is upregulated forming barriers with
astrocytes/fibroblasts and other extracellular matrix molecules, and thereby hampering …

Chondroitin sulphate (CS) is a sulphated glycosaminoglycan (GAG) polysaccharide found
on proteoglycans (CSPGs) in extracellular and pericellular matrices. Chondroitinase ABC …

Chondroitinase ABC (chABC) has evolved as a promising therapeutic for the degradation of
inhibitory chondroitin sulfate proteoglycans (CSPGs) after injury to the central nervous …

Chondroitin sulfate proteoglycans inhibit regeneration, neuroprotection, and plasticity
following spinal cord injury. The development of a second-generation chondroitinase ABC …

 Spinal cord injury causes physiological damage to nerve tissue and often lead to
permanent paralysis. The trauma activates the reactive astrocytes to secret high level of …

In recent studies related to injury to the central nervous system, researchers have found that
galactosaminoglycans can serve as inhibitors to neuron regeneration. The chondroitinase …

Utilizing enzyme therapy to repair the spinal cord injury has originated from the fact that
various types of chondroitin sulfate proteoglycans (CSPGs) are secreted in the glial scar by …