Understanding the neurobiological factors underlying individual differences in impulsivity
may provide valuable insight into vulnerability to impulse control disorders. Recent data …

Rationale Individual differences in impulsive decision-making may be critical determinants
of vulnerability to impulse control disorders and substance abuse, yet little is known of their …

Dysregulation of the prefrontal cortex (PFC) has been implicated in impulse control
disorders, including attention deficit hyperactivity disorder. A growing body of evidence …

The orbitofrontal cortex (OFC) and the medial prefrontal cortex (mPFC) modulate impulsive
behaviours. Serotonin [5-hydroxytryptamine (5-HT)] 2A receptors have also been implicated …

Impulsivity is characteristic of several mental health disorders and is largely mediated by the
prefrontal cortex subregions: the medial prefrontal cortex (mPFC) and the orbitofrontal cortex …

Impulsivity, which can be subdivided into impulsive action and impulsive choice, is
implicated as a factor underlying drug abuse vulnerability. Although previous research has …

Previous research has identified the nucleus accumbens (NAcb) as an important brain
region underlying inter-individual variation in impulsive behavior. Such variation has been …

Neuroimaging studies have implicated the insular cortex in cognitive processes including
decision making. Nonetheless, little is known about the mechanisms by which the insula …

Decisional impulsivity is one of the risk factors for occurrence and development of many
mental disorders, and that the dysfunctions of orbitofrontal cortex (OFC) and nucleus …

Rationale Lesions of the orbital prefrontal cortex (OPFC) can cause pathologically impulsive
behaviour in humans. Inter-temporal choice behaviour (choice between reinforcers differing …