[HTML][HTML] The promise of anti-ErbB3 monoclonals as new cancer therapeutics
In the last 3-5 years strong evidence has been gathered demonstrating ErbB3 as a key node
for the progression of several cancer types. From the mechanistic standpoint the intracellular …
for the progression of several cancer types. From the mechanistic standpoint the intracellular …
ErbB3 Inhibitory Surrobodies Inhibit Tumor Cell Proliferation In Vitro and In Vivo
PK Foreman, M Gore, PA Kobel, L Xu, H Yee… - Molecular cancer …, 2012 - AACR
ErbB3 is an important regulator of tumorigenesis and is implicated in development of
resistance to several currently used oncology drugs. We have identified ErbB3 inhibitors …
resistance to several currently used oncology drugs. We have identified ErbB3 inhibitors …
Potential of ErbB4 antibodies for cancer therapy
Antibodies targeting the extracellular domains of ErbB receptors have been extensively
studied for cancer drug development. This work has led to clinical approval of monoclonal …
studied for cancer drug development. This work has led to clinical approval of monoclonal …
[HTML][HTML] A new anti-ErbB2 strategy in the treatment of cancer: prevention of ligand-dependent ErbB2 receptor heterodimerization
J Baselga - Cancer Cell, 2002 - cell.com
Preventing ligand-dependent ErbB2 receptor heterodimers by an anti-ErbB2 monoclonal
antibody shuts down receptor signaling and has potent antitumor activity even in tumors that …
antibody shuts down receptor signaling and has potent antitumor activity even in tumors that …
The erbB family: targets for therapeutic development against cancer and therapeutic strategies using monoclonal antibodies and tyrosine kinase inhibitors
EK Rowinsky - Annu. Rev. Med., 2004 - annualreviews.org
The overexpression and aberrant function of members of the erbB family of receptors,
particularly erbB1 (also known as epidermal growth factor receptor), and its ligands in many …
particularly erbB1 (also known as epidermal growth factor receptor), and its ligands in many …
Emerging anti-cancer antibodies and combination therapies targeting HER3/ERBB3
N Gaborit, M Lindzen, Y Yarden - Human vaccines & …, 2016 - Taylor & Francis
Cancer progression depends on stepwise accumulation of oncogenic mutations and a
select group of growth factors essential for tumor growth, metastasis and angiogenesis …
select group of growth factors essential for tumor growth, metastasis and angiogenesis …
ErbB-directed immunotherapy: antibodies in current practice and promising new agents
E Friedländer, M Barok, J Szöllősi, G Vereb - Immunology letters, 2008 - Elsevier
The ErbB family is well known for its significance in oncogenesis. As bad prognostic
markers, overexpressed or mutated ErbB1 and ErbB2 have an important role in the …
markers, overexpressed or mutated ErbB1 and ErbB2 have an important role in the …
Effector mechanisms of therapeutic antibodies against ErbB receptors
M Peipp, M Dechant, T Valerius - Current opinion in immunology, 2008 - Elsevier
ErbB1 and ErbB2 constitute validated target antigens for tumor therapy—as documented by
the approval of antibodies and tyrosine kinase inhibitors (TKIs) against both antigens …
the approval of antibodies and tyrosine kinase inhibitors (TKIs) against both antigens …
Novel anti‐ErbB3 monoclonal antibodies show therapeutic efficacy in xenografted and spontaneous mouse tumors
L Aurisicchio, E Marra, L Luberto… - Journal of cellular …, 2012 - Wiley Online Library
The role of the ErbB3 receptor in signal transduction is to augment the signaling repertoire of
active heterodimeric ErbB receptor complexes through activating the PI3K/AKT pathway …
active heterodimeric ErbB receptor complexes through activating the PI3K/AKT pathway …
Novel anticancer targets: revisiting ERBB2 and discovering ERBB3
J Baselga, SM Swain - Nature Reviews Cancer, 2009 - nature.com
Aberrant receptor expression or functioning of the epidermal growth factor receptor (Erbb)
family plays a crucial part in the development and evolution of cancer. Inhibiting the …
family plays a crucial part in the development and evolution of cancer. Inhibiting the …