Identification of genetic loci simultaneously associated with multiple cardiometabolic traits
Background and aims Cardiometabolic disorders (CMD) arise from a constellation of
features such as increased adiposity, hyperlipidemia, hypertension and compromised …
features such as increased adiposity, hyperlipidemia, hypertension and compromised …
Population genomics of cardiometabolic traits: design of the university college london-london school of hygiene and tropical medicine-edinburgh-bristol (UCLEB) …
Substantial advances have been made in identifying common genetic variants influencing
cardiometabolic traits and disease outcomes through genome wide association studies …
cardiometabolic traits and disease outcomes through genome wide association studies …
Novel genetic loci associated with long-term deterioration in blood lipid concentrations and coronary artery disease in European adults
Background Cross-sectional genome-wide association studies have identified hundreds of
loci associated with blood lipids and related cardiovascular traits, but few genetic …
loci associated with blood lipids and related cardiovascular traits, but few genetic …
Familial co-aggregation and shared genetics of cardiometabolic disorders and traits: data from the multi-generational Lifelines Cohort Study
Background It is unclear to what extent genetics explain the familial clustering and the co-
occurrence of distinct cardiometabolic disorders in the general population. We therefore …
occurrence of distinct cardiometabolic disorders in the general population. We therefore …
Identification of susceptibility loci for cardiovascular disease in adults with hypertension, diabetes, and dyslipidemia
Background Hypertension (HTN), diabetes mellitus (DM), and dyslipidemia (DL) are well-
known risk factors of cardiovascular disease (CVD), but not all patients develop CVDs …
known risk factors of cardiovascular disease (CVD), but not all patients develop CVDs …
Whole‐genome approach discovers novel genetic and nongenetic variance components modulated by lifestyle for cardiovascular health
X Zhou, J Van Der Werf… - Journal of the …, 2020 - Am Heart Assoc
Background Both genetic and nongenetic factors can predispose individuals to
cardiovascular risk. Finding ways to alter these predispositions is important for …
cardiovascular risk. Finding ways to alter these predispositions is important for …
Bivariate genome-wide association scan identifies 6 novel loci associated with lipid levels and coronary artery disease
KM Siewert, BF Voight - Circulation: Genomic and Precision …, 2018 - Am Heart Assoc
Background: Plasma lipid levels are heritable and genetically associated with risk of
coronary artery disease (CAD). However, genome-wide association studies (GWAS) …
coronary artery disease (CAD). However, genome-wide association studies (GWAS) …
Evaluation of pleiotropic effects among common genetic loci identified for cardio-metabolic traits in a Korean population
YK Kim, MY Hwang, YJ Kim, S Moon, S Han… - Cardiovascular …, 2016 - Springer
Background The genetic contribution to complex diseases or traits, including cardio-
metabolic traits, has been elucidated recently by large-scale genome-wide association …
metabolic traits, has been elucidated recently by large-scale genome-wide association …
Lifestyle factors, genetic susceptibility to obesity and their interactions on coronary artery disease risk: A cohort study in the UK Biobank
Objective We aimed to evaluate potential modifying effects of genetic susceptibility to obesity
on the association of lifestyle factors with coronary artery disease (CAD) risk. Methods A total …
on the association of lifestyle factors with coronary artery disease (CAD) risk. Methods A total …
Genetic variants associated with cardiovascular diseases and related risk factors highlight novel potential therapeutic approaches
O Rom, YE Chen, M Aviram - Current opinion in lipidology, 2021 - journals.lww.com
Despite significant progress in diagnosis, medical treatment and drug development,
cardiovascular diseases (CVD) remain a leading cause of death. Atherosclerosis, the main …
cardiovascular diseases (CVD) remain a leading cause of death. Atherosclerosis, the main …