The replication-dependent histone mRNAs in metazoa are not polyadenylated, in contrast to
the bulk of mRNA. Instead, they contain an RNA stem–loop (SL) structure close to the 3 …

Metazoan replication-dependent histone mRNAs are not polyadenylated and instead end in
a conserved stem loop that is the cis element responsible for coordinate posttranscriptional …

The five histone proteins are encoded by a multigene family. In many organisms there is a
major tandemly repeated gene family with one copy of a gene for each histone in the re peat …

All metazoan messenger RNAs, with the exception of the replication-dependent histone
mRNAs, terminate at the 3′ end with a poly (A) tail. Replication-dependent histone mRNAs …

In principle, the formation of the 3 end of a eukaryotic mRNA is a simple process. At a
minimum, it involves the hydrolysis of a single phosphodiester bond in the nascent …

To study the substrate requirements for the histone 3′-end processing reaction of
mammalian histone pre-mRNAs, we created a set of mutations in the sequences flanking the …

Nearly all eukaryotic mRNAs end with a poly (A) tail that is added to their 3′ end by the
ubiquitous cleavage/polyadenylation machinery. The only known exceptions to this rule are …

The canonical histone proteins are encoded by replication-dependent genes and must
rapidly reach high levels of expression during S phase. In metazoans the genes that encode …

Metazoan histone mRNAs end in a highly conserved stem-loop structure followed by
ACCCA. Previous studies have suggested that the stem-loop binding protein (SLBP) is the …

Sequences at both the 5′ and 3′ ends of mouse histone genes contribute to the
expression of individual genes. The 3′ sequences required for high expression of the …