Background—Oxidative stress may contribute to heart failure (HF) progression. Inhibiting
xanthine oxidase in hyperuricemic HF patients may improve outcomes. Methods and …

BACKGROUND: Previous studies have not extensively examined the association of
hyperuricemia and adverse outcomes in systolic heart failure (HF) in relation to xanthine …

Increasing evidence suggests that serum uric acid (UA), a product of xanthine oxidase (XO),
may be a useful marker for metabolic, hemodynamic, and functional staging in heart failure …

The pathophysiologic understanding of chronic heart failure (CHF) has shifted from a mere
hemodynamic disorder to a much more complex approach including changes and …

Background—Hyperuricemia is common in chronic heart failure (CHF), and it is a strong
independent marker of prognosis. Upregulated xanthine oxidase (XO) activity and impaired …

Heart failure (HF) is a state of chronic deterioration of oxidative mechanisms due to
enhanced oxidative stress and consequent subcellular alterations. In this condition, oxidant …

Background—In patients with chronic heart failure (CHF), hyperuricemia is a common
finding and is associated with reduced vasodilator capacity and impaired peripheral blood …

Objectives: This study evaluated whether a xanthine oxidase (XO) inhibitor, oxypurinol,
produces clinical benefits in patients with New York Heart Association functional class III to …

BACKGROUND: Reactive oxygen species (ROS) have been linked to hypertrophy,
remodeling and abnormal excitation-contraction coupling. Previous data demonstrated that …

The role of hyperuricaemia as cardiovascular risk factor has exhaustingly been debated for
decades. While the association of elevated uric acid (UA) levels with increased mortality risk …