Actomyosin contractility affects cellular organization within tissues in part through the
generation of mechanical forces at sites of cell–matrix and cell–cell contact. While increased …

Cells integrate biochemical and mechanical information to function within multicellular
tissue. Within developing and remodeling tissues, mechanical forces contain instructive …

Adhesion-mediated signaling provides cells with information about multiple parameters of
their microenvironment, including mechanical characteristics. Often, such signaling is based …

Cell–cell junctions are specializations of the plasma membrane responsible for physically
integrating cells into tissues. We are now beginning to appreciate the diverse impacts that …

▪ Abstract The conversion of physical signals, such as contractile forces or external
mechanical perturbations, into chemical signaling events is a fundamental cellular process …

Mechanical stress is increasingly being shown to be a potent modulator of cell–cell
junctional morphologies in developmental and homeostatic processes. Intercellular force …

The propagation of force in epithelial tissues requires that the contractile cytoskeletal
machinery be stably connected between cells through E-cadherin-containing adherens …

Many essential cellular functions in health and disease are closely linked to the ability of
cells to respond to mechanical forces. In the context of cell adhesion to the extracellular …

In this study, we present results demonstrating that mechanotransduction by vascular
endothelial cadherin (VE-cadherin, also known as CDH5) complexes in endothelial cells …

Although Snail is essential for disassembly of adherens junctions during epithelial–
mesenchymal transitions (EMTs), loss of adherens junctions in Drosophila melanogaster …