Using the Olfactory System as an In Vivo Model To Study Traumatic Brain Injury and Repair

E Steuer, ML Schaefer, L Belluscio - Journal of neurotrauma, 2014 - liebertpub.com
Loss of olfactory function is an early indicator of traumatic brain injury (TBI). The
regenerative capacity and well-defined neural maps of the mammalian olfactory system …

Mild fluid percussion injury induces diffuse axonal damage and reactive synaptic plasticity in the mouse olfactory bulb

MA Powell, RT Black, TL Smith, TM Reeves, LL Phillips - Neuroscience, 2018 - Elsevier
Despite the regenerative capacity of the olfactory bulb (OB), head trauma causes olfactory
disturbances in up to 30% of patients. While models of olfactory nerve transection, olfactory …

[HTML][HTML] Traumatic brain injury-induced inflammatory changes in the olfactory bulb disrupt neuronal networks leading to olfactory dysfunction

X Liu, Z Lei, D Gilhooly, J He, Y Li, RM Ritzel… - Brain, Behavior, and …, 2023 - Elsevier
Abstract Approximately 20–68% of traumatic brain injury (TBI) patients exhibit trauma-
associated olfactory deficits (OD) which can compromise not only the quality of life but also …

Minocycline restores olfactory bulb volume and olfactory behavior after traumatic brain injury in mice

E Siopi, S Calabria, M Plotkine… - Journal of …, 2012 - liebertpub.com
Permanent olfactory dysfunction can often arise after traumatic brain injury (TBI) and while
one of the main causes is the immediate loss of neurons in the olfactory bulb (OB), the …

[HTML][HTML] Cortical contusion injury disrupts olfactory bulb neurogenesis in adult mice

KL Radomski, Q Zhou, KJ Yi, ML Doughty - BMC neuroscience, 2013 - Springer
Background Experimental brain trauma activates quiescent neural stem cells (NSCs) to
increase neuronal progenitor cell proliferation in the adult rodent brain. Previous studies …

In vivo imaging of functional disruption, recovery and alteration in rat olfactory circuitry after lesion

DJ Cross, JA Flexman, Y Anzai, TJ Morrow… - Neuroimage, 2006 - Elsevier
Compensatory changes following disruption of neuronal circuitry have been indicated by
previous imaging studies of stroke and other brain injury, but evidence of the pathways …

Sensory deprivation disrupts homeostatic regeneration of newly generated olfactory sensory neurons after injury in adult mice

S Kikuta, T Sakamoto, S Nagayama… - Journal of …, 2015 - Soc Neuroscience
Although it is well known that injury induces the generation of a substantial number of new
olfactory sensory neurons (OSNs) in the adult olfactory epithelium (OE), it is not well …

Alterations of brain gray matter density and olfactory bulb volume in patients with olfactory loss after traumatic brain injury

P Han, N Winkler, C Hummel, A Hähner… - Journal of …, 2018 - liebertpub.com
Olfactory loss and traumatic brain injury (TBI) both lead to anatomical brain alterations in
humans. Little research has been done on the structural brain changes for TBI patients with …

Olfactory nerve recovery following mild and severe injury and the efficacy of dexamethasone treatment

M Kobayashi, RM Costanzo - Chemical senses, 2009 - academic.oup.com
To investigate factors that influence the degree of neural regeneration and recovery, we
studied 2 olfactory nerve injury models. Transection of the olfactory nerves along the surface …

[HTML][HTML] Functional recovery of odor representations in regenerated sensory inputs to the olfactory bulb

MC Cheung, W Jang, JE Schwob… - Frontiers in neural …, 2014 - frontiersin.org
The olfactory system has a unique capacity for recovery from peripheral damage. After injury
to the olfactory epithelium (OE), olfactory sensory neurons (OSNs) regenerate and re …