Abstract Introduction Deregulation of Polycomb member Bmi-1 is involved in cell
proliferation and human oncogenesis. Modulation of Bmi-1 is found in several tumor tissues …

Purpose Abnormal expression of the cell cycle regulatory protein Bmi-1 has been studied in
breast cancer, but the clinical relevance has not been fully elucidated. We studied the …

Purpose BMI1, which is a major component of the polycomb group complex 1, is an
essential epigenetic repressor of multiple regulatory genes and has been identified as a …

Abstract Background Polycomb Group (PcG) proteins are epigenetic silencers involved in
maintaining cellular identity, and their deregulation can result in cancer. Expression of Mel …

Target molecules for a highly sensitive and specific diagnosis of breast cancer in its early
clinical stages have not yet been identified. Here, we show the first evidence for diagnostic …

The modulation of Bmi-1 is observed in several tumor tissues, and its heightened protein
level is suspected to be involved in tumorigenesis by acting as a transcriptional repressor in …

Background The purpose of present study was to examine the expression of cancer stem
cell marker Bmi-1 in breast cancer tissue and to evaluate the clinical implication of Bmi-1 …

Introduction: The polycomb group (PcG) proteins form chromatin-modifying complexes that
are commonly deregulated in cancer. The PcG protein BMI-I is overexpressed by various …

It is well documented that B cell-specific Moloney murine leukemia virus integration site 1
(Bmi-1), widely overexpressed in the vast majority of malignancies, plays an essential role in …

Purpose To investigate the clinicopathologic significance and predictive value of Bmi-1
expression in patients with colon cancer. Methods Bmi-1 expression was assessed by …