Pancreatic cancer is characterized by an expansive, desmoplastic stroma that responds to
neoplastic signals from the malignant epithelium while also instigating a cacophony of …

Bulk tumor tissues comprise intermixed populations of neoplastic cells and multiple lineages
of stromal cells. We used laser capture microdissection and RNA sequencing to disentangle …

Combining genomics with mathematical modeling provides a forecast system that can yield
computational predictions to anticipate cancer progression and therapeutic response. High …

Cancer progression and response to therapy are inextricably reliant on the co-evolution of a
supportive tissue microenvironment. This is particularly evident in pancreatic ductal …

Pancreatic ductal adenocarcinoma (PDA) is among the deadliest cancers in the United
States and in the world. Late diagnosis, early metastasis and lack of effective therapy are …

Pancreatic ductal adenocarcinoma co-opts multiple cellular and extracellular mechanisms to
create a complex cancer organ with an unusual proclivity for metastasis and resistance to …

Pancreatic ductal adenocarcinoma is one of the deadliest cancers, and its incidence on the
rise. The major challenges in overcoming the poor prognosis with this disease include late …

Bulk analyses of pancreatic ductal adenocarcinoma (PDAC) samples are complicated by the
tumor microenvironment (TME), ie signals from fibroblasts, endocrine, exocrine, and immune …

Abstract Pancreatic Ductal Adenocarcinoma (PDAC) is one of the most lethal cancers, with a
5-year survival rate of only 13%. PDAC develops from precursor lesions, most commonly …

Objective Pancreatic ductal adenocarcinoma (PDA) has among the highest stromal fractions
of any cancer and this has complicated attempts at expression-based molecular …