BOTH GENETIC AND ENVIRONMENTAL FACTORS CON-tribute to the pathogenesis of
type 2 diabetes mellitus (DM). Linkage analysis and genome-wide association studies have …

Context High-mobility group A1 (HMGA1) protein is a key regulator of insulin receptor
(INSR) gene expression. We previously identified a functional HMGA1 gene variant in 2 …

1) In contrast to the claims by Brunetti et al.(1), we have never reported in meeting abstracts
any consistent associations between HMGA1 variants and type 2 diabetes (T2D) risk when …

Type 2 diabetes mellitus (T2DM) is a complex disease in which both genetic and
environmental factors interact in determining impaired β-cell insulin secretion and peripheral …

It has recently been suggested that the low-frequency c. 136–14_136–13insC variant in high-
mobility group A1 (HMGA1) may strongly contribute to insulin resistance and type 2 diabetes …

Background: High-mobility group AT-hook 1 (HMGA1) is an important regulator of the insulin
receptor gene. We have previously shown in three populations of white European ancestry …

Background Recently, the high-mobility group A1 gene (HMGA1) variant IVS5-13insC has
been associated with type 2 diabetes, but reported associations are inconsistent and data …

Aims/hypothesis Variants of the high-mobility group A1 (HMGA1) gene have been shown to
be associated with insulin resistance and type 2 diabetes in individuals of European origin …

Background: Metabolic syndrome is partially heritable. High mobility group A1, an
architectural transcription factor, affects the homeostasis of glucose. The marked …

The high-mobility group A1 (HMGA1) gene has been previously identified as a potential
novel candidate gene for susceptibility to insulin resistance and type 2 diabetes (T2D) …