A major emphasis in cancer therapy research is finding mechanisms to enhance the
effectiveness of clinically used chemotherapeutic agents. In this report, we show the effects …

Cisplatin is one of the most widely used chemotherapeutic drugs for treating cancer. Initially,
platinum-based therapies are very effective in treating a wide array of cancers; however …

Objective To test whether nitric oxide (NO) enhances the cytotoxicity of cisplatin in a head
and neck squamous cell carcinoma (HNSCC) cell line. Background Cisplatin is one of the …

Melanoma patients experience inferior survival after biochemotherapy when their tumors
contain numerous cells expressing the inducible isoform of NO synthase (iNOS) and …

Nitric oxide is a key second messenger in most tissues, where it is generated at low
concentrations, predominantly by the catalytic action of two constitutively expressed isoforms …

The development of cancer cell resistance to various cytotoxic stimuli continues to be a
major challenge in oncology and novel therapeutic approaches are urgently needed. Nitric …

The potentiality to increase the chemotherapeutic effectiveness of some cytostatics in low,
subtherapeutic doses in combination with nitric oxide (NO) donor has been shown. This type …

Background: Hypoxia in tumors is associated with malignant progression, metastatic spread,
and increased resistance to radiotherapy and chemotherapy. Molecular O2 is required for …

Cisplatin treatment of rats results into a significant increase in the activity of Ca 2+-
independent nitric oxide synthase (NOS) in kidneys and liver. Significant enhancement of …

Recent evidence from experimental and clinical studies links the development of
intratumoral hypoxia and oxidative stress with malignant progression. Cellular adaptation …