Cell death is an essential phenomenon in normal development and homeostasis, but also
plays a crucial role in various pathologies. Our understanding of the molecular mechanisms …

Apoptosis or programmed cell death is a process with typical morphological characteristics
including plasma membrane blebbing, cell shrinkage, chromatin condensation and …

In order to eliminate cells that are redundant, damaged, or infected, metazoan organisms
have evolved the cell suicide mechanism termed apoptosis (Kerr et al. 1972). This genetic …

Like the organism they constitute, the cells also die in different ways. The death can be
predetermined, programmed, and cleanly executed, as in the case of apoptosis, or it can be …

Regulated cell death mediated by dedicated molecular machines, known as programmed
cell death, plays important roles in health and disease. Apoptosis, necroptosis and …

Nearly all physiological cell deaths in animals proceed by the process of apoptosis, during
which the dying cells vanish without a trace, silently cleared without any accompanying …

There are at least two major types of active or physiological cell death. The most well-known
form, apoptosis or Type I, involves early nuclear collapse, condensation of chromatin …

Since the initial description of apoptosis, a number of different forms of cell death have been
described. In this review we will focus on classic caspase-dependent apoptosis and its …

Apoptosis is co-ordinated by a family of cysteine proteases, the caspases, that dismantle the
cell by targeting a panoply of proteins for limited proteolysis. The mammalian caspase family …

Apoptosis is the regulated form of cell death utilized by metazoans to remove unneeded,
damaged, or potentially deleterious cells. Certain manifestations of apoptosis may be …