Intracellular heme is a redox active molecule that can be detrimental to cells at high
concentrations or under oxidizing conditions. To prevent accumulation, the inducible …

Recent investigations into the regulation of heme oxygenase-1 gene (hmox-1) transcription
have exposed mechanisms of increasing diversity and complexity worthy of a gene whose …

Oxidative stress activates the transcription factor NRF2, which in turn binds cis-acting
antioxidant response element (ARE) enhancers and induces expression of protective …

Heme oxygenase 1 (HO-1) catalyzes heme breakdown, eventually releasing iron, carbon
monoxide, and bilirubin IXα. HO-1 is induced by its substrate heme and various …

Stressed mammalian cells up-regulate heme oxygenase 1 (Hmox1; EC 1.14. 99.3), which
catabolizes heme to biliverdin, carbon monoxide, and free iron. To assess the potential role …

Heme oxygenase-1 (HO-1) degrades heme and protects cells from oxidative challenge. This
antioxidant activity is thought to result from the HO-1 enzymatic activity, manifested by a …

Bach1 is a member of the basic leucine zipper transcription factor family, and the
Bach1/small Maf heterodimer specifically represses transcriptional activity directed by the …

Heme oxygenase 1 (HO-1) is the first and rate-controlling enzyme in heme degradation.
Bach1 is a mammalian transcriptional repressor of HO-1. To understand how zinc …

The mammalian transcription factor Bach1 functions as a repressor of the enhancers of
heme oxygenase‐1 (HO‐1) gene (Hmox‐1) by forming heterodimers with the small Maf …

Heme is a key molecule in mediating the effects of oxygen on various molecular and cellular
processes in many living organisms. In the yeast Saccharomyces cerevisiae, heme serves …