Paclitaxel is a chemotherapeutic agent widely used for many types of malignancies.
However, when paclitaxel is used to treat tumors, patients commonly experience severe …

Background Paclitaxel is an antimitotic antitumour drug highly effective against a broad
range of cancers considered refractory to conventional chemotherapy. One of the main …

Paclitaxel, a powerful anti-neoplastic drug, often causes pathological pain, which
significantly reduces the quality of life in patients. Paclitaxel-induced pain includes pain that …

Paclitaxel chemotherapy frequently induces neuropathic pain during and often persisting
after therapy. The mechanisms responsible for this pain are unknown. Using a rat model of …

Background: Although paclitaxel is a frontline antineoplastic agent for treatment of solid
tumors, the paclitaxel-evoked pain syndrome is a serious problem for patients. There is …

Paclitaxel (Taxol®) is one of the most effective and frequently used chemotherapeutics for
the treatment of solid tumours. However, paclitaxel produces peripheral neurotoxicity with …

Purpose: Paclitaxel therapy often result in a unique subacute pain syndrome, commonly
termed “myalgia” or “arthralgia.” The pathophysiology of this syndrome is unknown and has …

Paclitaxel is an effective first-line chemotherapeutic with the major dose-limiting side effect of
painful neuropathy. Mitochondrial dysfunction and oxidative stress have been implicated in …

Background: Paclitaxel is an effective chemotherapeutic agent widely used for the treatment
of solid tumors. The major dose-limiting toxicity of paclitaxel is peripheral neuropathy. The …

Paclitaxel, one of the most commonly used cancer chemotherapeutic drugs, effectively
extends the progression-free survival of breast, lung, and ovarian cancer patients. However …