We have demonstrated previously that Ni (II) binds to the C-terminal− TESHHKAKGK motif of
isolated bovine histone H2A. At physiological pH, the bound Ni (II) assists in hydrolysis of …

Molecular mechanisms of nickel-induced carcinogenesis include interactions of Ni (II)
cations with histones. Previously, we demonstrated in vitro and in cells that Ni (II) cleaved off …

Over the last years, we have been testing a hypothesis that molecular mechanisms of nickel-
induced carcinogenesis include interactions of this metal with major chromatin components; …

A combined pH-metric and spectroscopic (UV/vis, CD, NMR) study of the Ni (II) binding to
CH3CO-Thr-Glu-Ser-His-His-Lys-NH2 (AcTESHHKam), a blocked hexapeptide modeling a …

Nickel, a well-established human carcinogen, was shown to decrease acetylation of
histones H4 and H3 in cultured cells. Such a decrease is expected to suppress gene …

Nickel (II) compounds are established human carcinogens, but the molecular mechanisms
underlying their activity are only partially known. One mechanism may include mediation by …

The acetyl-TESHHK-amide peptide, modeling a part of the C-terminal “tail” of histone H2A,
was found previously by us to undergo at pH 7.4 a Ni (II)-assisted hydrolysis of the E− S …

Although it has been well established that insoluble nickel compounds are potent
carcinogens and soluble nickel compounds are less potent, the mechanisms remain …

Ni (II) compounds are well known as human carcinogens, though the molecular events
which are responsible for this are not yet fully understood. It has been proposed that the …

The molecular mechanisms of nickel-induced malignant cell transformation include effects
altering the structure and covalent modifications of core histones. Previously, we found that …