Objective Although the osteoprotegerin (OPG)/RANK/RANKL system is the main modulator
of bone remodeling, it remains unclear whether it is regulated in cartilage during …

Objective. We determined whether osteoprotegerin (OPG) concentrations are associated
with established cardiovascular disease (CVD) among patients with rheumatoid arthritis …

Summary Objective Dickkopf-3 (Dkk3) is a non-canonical member of the Dkk family of Wnt
antagonists and its upregulation has been reported in microarray analysis of cartilage from …

Although a recent study suggested the involvement of RANKL and osteoprotegerin (OPG) in
the pathogenesis of bone-destructive disease, no study has focused on the RANKL: OPG …

Background Osteoprotegerin (OPG) and receptor activator of nuclear factor κ B ligand
(RANKL) play a critical role in the regulation of bone turnover, but the relative importance of …

OBJECTIVE: To clarify the regulation of osteoprotegerin (OPG) expression in rheumatoid
synovial fibroblasts by investigating the effect of tumor necrosis factor-alpha (TNF-alpha) …

BACKGROUND: Dickkopf-1 (DKK-1), an inhibitor of the Wnt pathway, has recently emerged
as an important player in several critical aspects of bone biology. METHODS: We performed …

Abstract Psoriatic Arthritis (PsA) is characterized by bone erosive damage often associated
with exuberant bone formation especially in enthesial sites. Dkk-1 and sclerostin are the …

Objective To determine whether proinflammatory cytokine treatment or the complete
absence of select cytokines modulates the expression of RANKL and osteoprotegerin (OPG) …

Introduction Rat adjuvant-induced arthritis (AIA) and collagen-induced arthritis (CIA) feature
bone loss and systemic increases in TNFα, IL-1β, and receptor activator of NF-κB ligand …