Introduction Inflammatory arthritis is associated with increased bone resorption and
suppressed bone formation. The Wnt antagonist dickkopf-1 (DKK1) is secreted by synovial …

Osteoprotegerin (OPG), a soluble decoy receptor for receptor activator of nuclear factor κB
ligand, is implicated in the pathogenesis of atherosclerosis. Patients with rheumatoid arthritis …

Dickkopf-1 (Dkk-1) is a Wnt signaling pathway inhibitor that has been shown to play an
important role in joint remodeling, in experimental models of arthritis and in humans. Recent …

Osteoprotegerin (OPG) and the receptor activator of nuclear factor (NF)-kB ligand (RANKL)
are key regulators of osteoclastogenesis. The present study had the main aim of showing …

The discovery of receptor activator for nuclear factor kappaB ligand (RANKL) and
osteoprotegerin (OPG) as the fundamental factors in controlling osteoclast formation and …

The Wnt/β‐catenin pathway is a major signaling cascade in bone biology, playing a key role
in regulating bone development and remodeling, with aberrations in signaling resulting in …

Introduction: Rheumatoid arthritis (RA) is associated with focal and systemic bone loss
involving cytokines such as RANKL and TNF-α. RANK-L promotes focal and systemic …

The determinants of cancellous bone turnover and trabecular structure are not understood in
normal bone or skeletal disease. Bone remodeling is initiated by osteoclastic resorption …

Objective Tumor necrosis factor (TNF) drives bone destruction, but it also inhibits new bone
formation by inducing Dkk‐1, an inhibitor of the Wnt pathway. Accordingly, blocking of Dkk‐1 …

Recently, novel members of the TNF/TNF receptor superfamily, receptor activator of nuclear
factor-κ B ligand (RANKL), its receptor RANK, and the decoy receptor osteoprotegerin …