Objective. This study investigated the involvement of the recently identified regulators of
osteoclast formation RANKL [receptor activator of nuclear factor kappaB (RANK) ligand …

Objective To determine to what extent baseline measurements of the ratio receptor activator
of nuclear factor-κB ligand (RANKL): osteoprotegerin (OPG) and C-terminal cross linking of …

Fracture healing is a unique biological process regulated by a complex array of signaling
molecules and proinflammatory cytokines. Recent evidence for the role of tumor necrosis …

Aim: Our objective of this study is to investigate the relationship between plasma
osteoprotegerin (OPG) levels in type 2 diabetes and its relationship with the insulin …

OBJECTIVE: Dysregulated Wnt signaling appears to modulate chondrocyte fate and joint
disorders. Dickkopf-1 (DKK1) regulates the pathogenesis of skeletal tissue by inhibiting Wnt …

Recent animal and clinical studies have suggested that Dkk-1, a secreted inhibitor of the
canonical Wnt signalling pathway, could play an important role in mediating the alterations …

Abstract Objective Perturbation of Wnt signaling components reportedly regulates
chondrocyte fate and joint disorders. The Wnt inhibitor Dkk‐1 mediates remodeling of …

Background Pro-inflammatory cytokines possess osteoclastogenic or anti-osteoclastogenic
activities. They influence osteoclasts directly or via the receptor activator of nuclear factor κB …

Objective To characterize bone microarchitectural changes and to test the hypothesis that
disrupting local cytokine equilibrium could modify cartilage degradation in a murine model of …

Osteoprotegerin ligand (OPGL) is a newly discovered molecule which is essential for
osteoclast differentiation. Both OPGL and its soluble decoy receptor, osteoprotegerin (OPG) …