A healthy skeleton depends on a continuous renewal and maintenance of the bone tissue.
The process of bone remodeling is highly controlled and consists of a fine-tuned balance …

Wnt signaling plays a pivotal role in maintaining bone mass. Secreted pathway modulators
such as sclerostin (SOST) and Dickkopfs (DKKs) may influence bone mass inhibiting the …

Objective To clarify the mechanism by which osteoclasts are formed in culture of rheumatoid
synoviocytes by exploring the involvement of receptor activator of nuclear factor κB ligand …

Objective To demonstrate the effects of disease‐modifying antirheumatic drugs and
antiinflammatory cytokines on human osteoclastogenesis through their effects on receptor …

Osteoporosis is a recognised complication of axial spondyloarthritis (axSpA) and is thought
to be due to functional impairment and the osteoclast-activating effects of proinflammatory …

Rheumatoid arthritis is characterized by progressive synovial inflammation and joint
destruction. While matrix metalloproteinases (MMPs) are implicated in the erosion of …

The measurement of body fluid levels of biochemical markers in joint tissues has begun to
provide clinically useful information. Synovial fluid (SF) plays an important role in articular …

Abstract Objective Dickkopf-1 (DKK-1) is an endogenous inhibitor of canonical Wnt pathway
that was implicated in the pathogenesis of rheumatoid arthritis (RA), but the serum levels of …

Rheumatoid arthritis is characterized by the presence of inflammatory synovitis and
destruction of joint cartilage and bone. Tissue proteinases released by synovia …

Biochemical markers reflecting joint remodeling in osteoarthritis (OA) are a promising
diagnostic tool. The aim of this study was to investigate serum levels of candidate …