Recent healthcare problems in the field of dermatology have heightened the need for novel
therapeutic approaches. The limitations of conventional methods for wound management …

Historically, efforts in the medical and biomedical engineering fields have been directed not
only at preserving the health and integrity of existing tissues and organs, but also toward …

Significant progress has been made in the development of in vitro‐engineered skin
substitutes that mimic human skin, either to be used for the replacement of lost skin or for the …

Grafting of skin or mucosa to the oral cavity involves challenging surgical techniques to
solve a vast number of clinical problems in dentistry and oral and maxillofacial surgery …

Skin loss due to burns or ulcers is a major medical problem and is the motivation for the
development of skin substitutes and skin replacement technologies, many of which have …

Engineering skin substitutes provides a potential source of advanced therapies for the
treatment of acute and chronic wounds. Cultured skin substitutes (CSS) consisting of human …

Wounds that exhibit delayed healing have a tremendous impact on health care expenditures
and place patients at serious risk for severe complications including death. The healing of a …

There are various artificial skin substitutes available commercially. The authors have used
Integra, cultured epithelium, and Apligraf in their clinic. In the present report, they present …

BACKGROUND Human Skin Substitute (Apligraf, Organogenesis, Inc., Canton, MA) is a bi-
layered tissue-engineered living biological dressing developed from neonatal foreskin. It …