Impact of lymphangiogenesis on cardiac remodeling after ischemia and reperfusion injury

Y Shimizu, R Polavarapu, KL Eskla… - Journal of the …, 2018 - Am Heart Assoc
Background Lymphatic vessels interconnect with blood vessels to form an elaborate system
that aids in the control of tissue pressure and edema formation. Although the lymphatic …

Selective stimulation of cardiac lymphangiogenesis reduces myocardial edema and fibrosis leading to improved cardiac function following myocardial infarction

O Henri, C Pouehe, M Houssari, L Galas, L Nicol… - Circulation, 2016 - Am Heart Assoc
Background—The lymphatic system regulates interstitial tissue fluid balance, and lymphatic
malfunction causes edema. The heart has an extensive lymphatic network displaying a …

Lymphatic and immune cell cross-talk regulates cardiac recovery after experimental myocardial infarction

M Houssari, A Dumesnil, V Tardif, R Kivelä… - … , and vascular biology, 2020 - Am Heart Assoc
Objective: Lymphatics play an essential pathophysiological role in promoting fluid and
immune cell tissue clearance. Conversely, immune cells may influence lymphatic function …

[HTML][HTML] The role of lymphangiogenesis in cardiovascular diseases and heart transplantation

RC Ji - Heart Failure Reviews, 2022 - Springer
Cardiac lymphangiogenesis plays an important physiological role in the regulation of
interstitial fluid homeostasis, inflammatory, and immune responses. Impaired or excessive …

Regulation and impact of cardiac lymphangiogenesis in pressure-overload-induced heart failure

C Heron, A Dumesnil, M Houssari… - Cardiovascular …, 2023 - academic.oup.com
Aims Lymphatics are essential for cardiac health, and insufficient lymphatic expansion
(lymphangiogenesis) contributes to development of heart failure (HF) after myocardial …

[HTML][HTML] Cardiac macrophage subsets differentially regulate lymphatic network remodeling during pressure overload

M Bizou, R Itier, M Majdoubi, D Abbadi, E Pichery… - Scientific Reports, 2021 - nature.com
The lymphatic network of mammalian heart is an important regulator of interstitial fluid
compartment and immune cell trafficking. We observed a remodeling of the cardiac …

[HTML][HTML] Genetic blockade of lymphangiogenesis does not impair cardiac function after myocardial infarction

TCS Keller, L Lim, SV Shewale… - The Journal of …, 2021 - Am Soc Clin Investig
In recent decades, treatments for myocardial infarction (MI), such as stem and progenitor cell
therapy, have attracted considerable scientific and clinical attention but failed to improve …

Cardiac lymphatic vessels, transport, and healing of the infarcted heart

LH Huang, KJ Lavine, GJ Randolph - Basic to Translational Science, 2017 - jacc.org
The lymphatic vasculature plays a key role in regulating tissue fluid homeostasis, lipid
transport, and immune surveillance throughout the body. Although it has been appreciated …

[HTML][HTML] The evolving cardiac lymphatic vasculature in development, repair and regeneration

K Klaourakis, JM Vieira, PR Riley - Nature Reviews Cardiology, 2021 - nature.com
The lymphatic vasculature has an essential role in maintaining normal fluid balance in
tissues and modulating the inflammatory response to injury or pathogens. Disruption of …

Formation and growth of cardiac lymphatics during embryonic development, heart regeneration, and disease

D Gancz, G Perlmoter, K Yaniv - Cold Spring Harbor …, 2020 - cshperspectives.cshlp.org
The lymphatic system plays crucial roles in regulating fluid homeostasis, immune
surveillance, and lipid transport. As is in most of the body's organs, the heart possesses an …