Retrospective gating (RG) is a well established technique in preclinical computed
tomography (CT) to assess 3D morphology of the lung. In RG additional angular projections …

Micro-CT will have a profound influence on the accumulation of anatomical and
physiological phenotypic changes in natural and transgenetic mouse models. Longitudinal …

RATIONALE: disease, imaging should provide both dynamic and spatially resolved
measurement of lung function. Most lung function measurement methods are unable to …

Synchrotron X-ray sources have unique capabilities for in vivo imaging of the lungs in small
animals. The moving, breathing lungs can be captured in detail due to the high brightness …

The current standard for lung function evaluation in murine models is based on forced
oscillation technology, which provides a measure of the total airway function but cannot …

As pulmonary functional imaging moves beyond the realm of the radiologist and physicist, it
is important that imagers have a common language and understanding of the relevant …

In this thesis, we describe several imaging techniques specifically designed and developed
for the assessment of pulmonary structure, function and pathology. We then describe the …

Live imaging is critical to determining the dynamics and spatial interactions of cells within
the tissue environment. In the lung, this has proven to be difficult due to the motion incurred …

Molecular imaging is a rapidly developing multidisciplinary field that combines advances in
contrast agent development, instrumentation, and molecular/cell biology to follow cellular …

Characterization and noninvasive measurement of molecular pathways and biochemistry in
living cells, animal models, and humans at the cellular and molecular level is now possible …