The genesis for this Special Issue devoted to “3D Imaging in Lung Biology” emerged when
the two of us met for the first time as faculty at the Jackson Laboratory's course,“Phenotyping …

Conclusions: Our results demonstrate that large area comprehensive microscopy of the
pulmonary airways is possible. We anticipate that the translation of OFDI based …

Imaging of the airways is a fascinating undertaking and, if done expertly, a true art in
medicine. Over the past years, imaging of the airways has become ever more exciting and …

High-resolution X-ray CT imaging can provide detailed structural and functional information
about the respiratory system. We describe a software system to facilitate quantitative …

The delicate structure of murine lungs poses many challenges for acquiring high-quality
images that truly represent the living lung. Here, we describe several optimized procedures …

Background The biomechanical properties of the lung are necessarily dependent on its
structure and function, both of which are complex and change over time and space. This …

Purpose: In order to standardize quantitative lung CT for the COPDGene Study, a custom
designed, commercially available (Phantom Labs, Greenwich, NY) phantom has been …

Utilizing micro-X-ray CT (μCT) imaging, we sought to generate an atlas of in vivo and
intact/ex vivo lungs from normal murine strains. In vivo imaging allows visualization of …

1974 Objectives Alterations in regional lung morphology are indicative of pathological
changes in the lung. Accurate estimation of morphology-related metrics, particularly volume …

Research on lung development and disease frequently utilizes mouse models to conduct in
vitro experiments. Such experiments involve multiple methodologically distinct stages, from …