Extracellular vesicles (EVs) contribute to intercellular communication through the transfer of
their rich cargo to recipient cells. The EVs produced by LPS-stimulated neutrophils from …

OBJECTIVE Neutrophilic inflammation is associated with the degree of airway obstruction in
severe equine asthma (SEA), but the contribution of these leukocytes to bronchial …

Asthma encompasses a spectrum of heterogenous immune-mediated respiratory disorders
sharing a similar clinical pattern characterized by cough, wheeze and exercise intolerance …

Neutrophils infiltrate the airways of patients with asthma of all severities, yet their role in the
pathogenesis of asthma and their contribution to airway remodeling is largely unknown. We …

Extracellular vesicles (EVs) are membrane-bound particles that engage in inflammatory
reactions by mediating cell–cell interactions. Previously, EVs have been isolated from the …

Background Severe neutrophilic asthma is poorly responsive to glucocorticosteroids (GC).
Neutrophil extracellular traps (NETs) within the lungs have been associated with the severity …

Asthma is a common and debilitating chronic airway disease that affects people and horses
of all ages worldwide. While asthma in humans most commonly involves an excessive type …

Heaves, an obstructive neutrophilic airway inflammation of horses, is triggered by dust
components such as endotoxin and has similarities to human asthma. Pulmonary …

Studying the proteomes of tissue-derived extracellular vesicles (EVs) can lead to the
identification of biomarkers of disease and can provide a better understanding of cell-to-cell …

Neutrophils display an array of biological functions including the formation of neutrophil
extracellular traps (NETs), web-like structures specialized in trapping, neutralizing, killing …