Osteocytes reside as a cellular network throughout the mineralised matrix of bone and are
considered the primary mechanosensors of this tissue. They sense mechanical stimulation …

Osteocytes are considered the primary mechanosensors of bone, but the signaling
pathways they apply in mechanotransduction are still incompletely investigated and …

Osteocytes' response to dynamic loading plays a crucial role in regulating the bone mass
but quickly becomes saturated such that downstream induction of bone formation plateaus …

ABSTRACT ATP release and subsequent activation of purinergic receptors has been
suggested to be one of the key transduction pathways activated by mechanical stimulation of …

We previously demonstrated, using osteoblastic MC3T3-E1 cells, that P2Y2 purinergic
receptors are involved in osteoblast mechanotransduction. In this study, our objective was to …

The P2X 7 nucleotide receptor (P2X 7 R) is an ATP-gated ion channel expressed in many
cell types including osteoblasts and osteocytes. Mice with a null mutation of P2X 7 R have …

There are differences between osteoclasts and osteoblastic cells in their cytosolic calcium
responses to purinergic receptor activation. Application of 50 or 100 μM extracellular ATP …

The P2 purinergic receptor family implicated in many physiological processes, including
neurotransmission, mechanical adaptation and inflammation, consists of ATP-gated non …

Nucleotides, released in response to mechanical or inflammatory stimuli, signal through P2
nucleotide receptors in many cell types. Osteoclasts express P2X7 receptors (encoded by …

Extracellular nucleotides such as ATP and UTP are released in response to mechanical
stimulation in different cell systems. It is becoming increasingly evident that ATP release …