Prefusion-stabilized SARS-CoV-2 S2-only antigen provides protection against SARS-CoV-2 challenge
Abstract Ever-evolving SARS-CoV-2 variants of concern (VOCs) have diminished the
effectiveness of therapeutic antibodies and vaccines. Developing a coronavirus vaccine that …
effectiveness of therapeutic antibodies and vaccines. Developing a coronavirus vaccine that …
Vaccine-elicited murine antibody WS6 neutralizes diverse beta-coronaviruses by recognizing a helical stem supersite of vulnerability
W Shi, L Wang, T Zhou, M Sastry, ES Yang, Y Zhang… - Structure, 2022 - cell.com
Immunization with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike
elicits diverse antibodies, but it is unclear if any of the antibodies can neutralize broadly …
elicits diverse antibodies, but it is unclear if any of the antibodies can neutralize broadly …
Structural basis and mode of action for two broadly neutralizing antibodies against SARS-CoV-2 emerging variants of concern
Emerging variants of concern for the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) can transmit more efficiently and partially evade protective immune …
(SARS-CoV-2) can transmit more efficiently and partially evade protective immune …
Engineered immunogens to elicit antibodies against conserved coronavirus epitopes
Immune responses to SARS-CoV-2 primarily target the receptor binding domain of the spike
protein, which continually mutates to escape acquired immunity. Other regions in the spike …
protein, which continually mutates to escape acquired immunity. Other regions in the spike …
SARS-CoV-2 S2–targeted vaccination elicits broadly neutralizing antibodies
Several variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have
emerged during the current coronavirus disease 2019 (COVID-19) pandemic. Although …
emerged during the current coronavirus disease 2019 (COVID-19) pandemic. Although …
A broadly generalizable stabilization strategy for sarbecovirus fusion machinery vaccines
Evolution of SARS-CoV-2 alters the antigenicity of the immunodominant spike (S) receptor-
binding domain and N-terminal domain, undermining the efficacy of vaccines and antibody …
binding domain and N-terminal domain, undermining the efficacy of vaccines and antibody …
SARS-CoV-2 protein subunit vaccination of mice and rhesus macaques elicits potent and durable neutralizing antibody responses
The outbreak and spread of SARS-CoV-2 (severe acute respiratory syndrome-coronavirus-
2) is a current global health emergency, and effective prophylactic vaccines are needed …
2) is a current global health emergency, and effective prophylactic vaccines are needed …
Structural and computational design of a SARS-CoV-2 spike antigen with improved expression and immunogenicity
JA Williams, M Biancucci, L Lessen, S Tian… - Science …, 2023 - science.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern
challenge the efficacy of approved vaccines, emphasizing the need for updated spike …
challenge the efficacy of approved vaccines, emphasizing the need for updated spike …
Protein-based SARS-CoV-2 spike vaccine booster increases cross-neutralization against SARS-CoV-2 variants of concern in non-human primates
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants
that partly evade neutralizing antibodies raises concerns of reduced vaccine effectiveness …
that partly evade neutralizing antibodies raises concerns of reduced vaccine effectiveness …
Multivalent S2-based vaccines provide broad protection against SARS-CoV-2 variants of concern and pangolin coronaviruses
PJ Halfmann, SJ Frey, K Loeffler, M Kuroda… - …, 2022 - thelancet.com
Background The COVID-19 pandemic continues to cause morbidity and mortality worldwide.
Most approved COVID-19 vaccines generate a neutralizing antibody response that primarily …
Most approved COVID-19 vaccines generate a neutralizing antibody response that primarily …