Previous studies have suggested a role for c-fos in cellular differentiation in fetal membranes
1–3, haematopoietic cells4, 5 and teratocarcinoma stem cells6. In other cell types, such as …

The 3′ noncoding region (NCR) AU-rich element (ARE) selectively confers rapid
degradation on many mRNAs via a process requiring translation of the message. The role of …

The transient induction of c-fos mRNA and protein suggests that regulation occurs not only
by transcriptional activation but also at the level of turnover of the gene product. Here we …

The mRNAs of transiently expressed genes frequently contain an AU-rich sequence in the
B'untranslated region. We introduced a 51 nucleotide AT sequence from a human …

The time of onset of transcriptional activity in the early mammalian embryo is unclear. RNA
synthesis has been shown to occur at the two-cell stage in the mouse1–4 and at the two-to …

THE degradation of messenger RNA in eukaryotic cells is initiated by endonucleolytic
cleavage1, 2 or by shortening of the poly (A) tail3–6, which for some mRNAs activates a …

Serum-induced transcription of the proto-oncogene fos is under negative feedback
regulation mediated by the fos protein. The fos promoter region responsive to repression is …

Abstract POLYADENYLIC acid, poly (A), which was discovered some time ago in
mammalian cells1, 2, originates in the cell nucleus as part of HnRNA* and is also found in …

THE products of the cellular and retroviral fos genes associate with other nuclear proteins1,
2, among them the transcription factor APl/Jun (see ref. 3 for a review). The Fos/Jun complex …

Sequences upstream from the proto-oncogene fos were shown to be essential for its
transcription. Transient expression of the chloramphenicol acetyltransferase (CAT) gene …