IT is commonly assumed that the messenger RNA (mRNA) of prokaryotes lacks the poly (A)
sequences which characterise the 3′ terminus of most mRNA of eukaryotes. A report of the …

Abstract mRNA turnover mediated by the major protein-coding-region determinant of
instability (mCRD) of the c-fos proto-oncogene transcript illustrates a functional interplay …

THE origin of the RNA world1 is not easily understood, as effective prebiotic syntheses of the
components of RNA, the β-ribofurano-side-5′-phosphates, are hard to envisage2 …

c-fos mRNA accumulates to a level of 0.2% of cellular poly (A)-containing RNA 45 min after
treatment of rat pheochromocytoma (PC12) cells with 1 mM barium chloride. Several clones …

Teratocarcinoma cells provide us with a model system for the study of differentiation and
development1–3. One of the best characterized cell lines, the embryonal carcinoma stem …

Novel protein-coding genes can arise either through re-organization of pre-existing genes or
de novo,. Processes involving re-organization of pre-existing genes, notably after gene …

THE Jun proteins are nuclear proteins that combine with Fos proteins to form a gene-
regulatory protein, AP-1. They have highly conserved DNA-binding and dimerization …

Several recent studies have shown that a functional poly (A) site consists of both an
AAUAAA element as well as sequences downstream of the cleavage site. Two downstream …

Abstract Small (< 200 nucleotide) RNA (sRNA) profiling of human cells using various
technologies demonstrates unexpected complexity of sRNAs with hundreds of thousands of …

As an undergraduate at Cambridge I intended to study chemistry, but took a cell and
molecular biology course as well. I realized that the molecular basis of life is really chemistry …